Download E-books The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level PDF

By Jessica Wapner

A Wall road Journal 10 most sensible Nonfiction e-book of the Year

“Among a small cluster of first-class fresh books on cancer.” —The long island Times

Philadelphia, 1959: A scientist scrutinizing a unmarried human telephone less than a microscope detects a lacking piece of DNA. That scientist, David Hungerford, had no approach of figuring out that he had stumbled upon the start line of contemporary melanoma study— the Philadelphia chromosome. it can take medical professionals and researchers all over the world greater than 3 many years to solve the consequences of this landmark discovery. In 1990, the Philadelphia chromosome used to be well-known because the sole explanation for a perilous blood melanoma, persistent myeloid leukemia, or CML. melanoma learn could by no means be the same.

technological know-how journalist Jessica Wapner reconstructs greater than 40 years of an important breakthroughs, basically explains the technological know-how at the back of them, and can pay tribute—with wide unique reporting, together with greater than thirty-five interviews—to the handfuls of researchers, medical professionals, and sufferers with an immediate position during this inspirational tale. Their interest and backbone might finally bring about a lifesaving remedy not like whatever ahead of it.

The Philadelphia Chromosome chronicles the extraordinary swap of fortune for the greater than 70,000 humans around the globe who're clinically determined with CML every year. it's a get together of an extraordinary triumph within the conflict opposed to melanoma and a blueprint for destiny learn, as medical professionals and scientists race to discover and deal with the genetic roots of quite a lot of cancers.

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Download E-books High-Yield Gastrointestinal Tract (1st Edition) (High-Yield Series) PDF

By Ronald W. Dudek

High-Yield Gastrointestinal Tract is the 5th in a chain of High-Yield Systems books through a best-selling clinical textbook writer that disguise the elemental sciences of the clinical university curriculum utilizing a systems-based process. This process is helping scholars combine their first years' direction fabric and gives very good practise for USMLE Step 1 and medical rotations.

Chapters assessment every one simple science—embryology, gross anatomy, radiology, histology, body structure, pathology, microbiology, and pharmacology—as it pertains to the entire organs alongside the gastrointestinal tract. The ebook is replete with radiographs, CT and MRI scans, and micrographs of ordinary tissue and pathologic stipulations.

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Download E-books Living with the Changing California Coast PDF

Crowded into the gorgeous, slim strip on the fringe of the sea, the massive variety of those that stay close to California's dynamic sea coast frequently have little knowledge of the hazards—waves, tides, wind, storms, rain, and runoff—that erode and impression the coast and declare estate regularly. This up to date, authoritative, and easy-to-use e-book, a geological profile of the California coast from Mexico to the Oregon border, describes the landforms and procedures that form the beach and shores, files how erosion has affected improvement, and discusses the choices which are to be had for facing coastal dangers and geologic instability.

A thoroughly revised and up to date version of Living with the California Coast (1985), this booklet good points countless numbers of latest pictures and the most recent info on human task at the coast, on weather swap, on emerging seas degrees, and on coastal erosion and security. With its dramatic pictures and mile-by-mile maps, Living with the altering California Coast will be a necessary source for these meaning to purchase or construct alongside the coast, those that desire particular information regarding a variety of coastal areas, and people who are trying to find information regarding how this notable beach has evolved.

*279 pictures painting average coastal positive aspects and procedures and illustrate many situations of what can take place to constructions at the coast

*81 maps, protecting the full coast, aspect kinds of coastal landforms, beach erosion premiums, destinations of seawalls or armor, and different particular parts of interest

*Offers particular suggestion for homebuyers,residents, and builders on which parts to prevent, on what defense measures may be taken, and on what possibility signs might be heeded

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Download E-books Enhancing Evolution: The Ethical Case for Making Better People PDF

By John Harris

In Enhancing Evolution, best bioethicist John Harris dismantles objections to genetic engineering, stem-cell examine, clothier infants, and cloning and makes a moral case for biotechnology that's either forthright and rigorous. Human enhancement, Harris argues, is an efficient thing--good morally, sturdy for people, solid as social coverage, and solid for a genetic background that wishes severe development. Enhancing Evolution defends biotechnological interventions which may let us dwell longer, fitter, or even happier lives by means of, for instance, offering us with immunity from melanoma and HIV/AIDS. extra, Harris champions the potential of influencing the very process evolution to provide us elevated psychological and actual powers--from reasoning, focus, and reminiscence to power, stamina, and response velocity. certainly, he says, it is not merely morally defensible to augment ourselves; at times, it really is morally obligatory.

In a brand new preface, Harris deals a glimpse on the new technology and expertise to come back, equipping readers with the data to evaluate the ethics and coverage dimensions of destiny different types of human enhancement.

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Download E-books The Violinist's Thumb: And Other Lost Tales of Love, War, and Genius, as Written by Our Genetic Code PDF

By Sam Kean

From New York instances bestselling writer Sam Kean comes extra superb tales of technological know-how, background, language, and tune, as instructed by means of our personal DNA.

In The Disappearing Spoon, bestselling writer Sam Kean unlocked the mysteries of the periodic desk. within the VIOLINIST'S THUMB, he explores the wonders of the mystical development block of lifestyles: DNA.

There are genes to provide an explanation for loopy cat girls, why people don't have any fingerprints, and why a few humans live on nuclear bombs. Genes light up every thing from JFK's bronze dermis (it wasn't a tan) to Einstein's genius. They turn out that Neanderthals and people bred millions of years extra lately than any people could think cozy considering. they could even let a few humans, as a result of the unheard of flexibility in their thumbs and palms, to turn into really singular violinists.

Kean's brilliant storytelling once more makes technological know-how wonderful, explaining human heritage and whimsy whereas exhibiting how DNA will impression our species' future.

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Download E-books Deadly Choices: How the Anti-Vaccine Movement Threatens Us All PDF

In 2014, California suffered the most important and deadliest outbreak of pertussis, often referred to as “whooping cough,” in additional than fifty years. This tragedy used to be avoidable. a good vaccine has been on hand because the Forties. lately different ailments, like measles and mumps, have additionally made a comeback. the cause of those epidemics might be traced to a gaggle whose vocal proponents insist, regardless of proof on the contrary, that vaccines are poison. in this case, mom and dad and caretakers are rejecting vaccines for themselves and their families.

In Deadly Choices, infectious-disease specialist Paul Offit takes a glance backstage of the anti-vaccine move. What he unearths is a reminder of the facility of medical wisdom, and the damage we threat if we forget about it.

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Download E-books The Theory That Would Not Die: How Bayes' Rule Cracked the Enigma Code, Hunted Down Russian Submarines, and Emerged Triumphant from Two Centuries of Controversy PDF

By Sharon Bertsch McGrayne

Bayes' rule seems to be a simple, one-line theorem: through updating our preliminary ideals with goal new details, we get a brand new and more suitable trust. To its adherents, it truly is a sublime assertion approximately studying from adventure. To its competitors, it truly is subjectivity run amok.

In the first-ever account of Bayes' rule for common readers, Sharon Bertsch McGrayne explores this debatable theorem and the human obsessions surrounding it. She strains its discovery by way of an novice mathematician within the 1740s via its improvement into approximately its smooth shape via French scientist Pierre Simon Laplace. She finds why revered statisticians rendered it professionally taboo for a hundred and fifty years—at a similar time that practitioners trusted it to unravel crises related to nice uncertainty and scanty details (Alan Turing's function in breaking Germany's Enigma code in the course of international struggle II), and explains how the appearance of off-the-shelf laptop expertise within the Eighties proved to be a game-changer. this day, Bayes' rule is used in every single place from DNA de-coding to native land Security.

Drawing on fundamental resource fabric and interviews with statisticians and different scientists, the speculation that may no longer Die is the riveting account of the way a likely easy theorem ignited one of many maximum controversies of all time.

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Download E-books Plant Cell Culture Protocols (Methods in Molecular Biology (Cloth)) PDF

Robert corridor and a panel of professional researchers current a complete selection of the main usually used and greatly acceptable strategies for plant phone and tissue tradition. effortlessly reproducible and broadly annotated, the tools hide tradition initiation, upkeep, manipulation, software, and long term garage, with emphasis on recommendations for genetic amendment and micropropagation. a lot of those protocols are at present utilized in significant tasks designed to supply more advantageous different types of very important crop crops. Plant mobilephone tradition Protocols's cutting-edge strategies are bound to make the publication contemporary reference of selection, an essential software within the improvement of latest transgenic vegetation and full-scale advertisement functions.

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Download E-books Handbook of Nanobiomedical Research : Fundamentals, Applications and Recent Developments (In 4 Volumes) (Frontiers in Nano Biomedical Research) PDF

This publication comprises four volumes containing approximately 70 chapters protecting the entire significant elements of the turning out to be zone of nanomedicine. best scientists from 15 nations conceal all significant components of nanobiomedical study — fabrics for nanomedicine, software of nanomedicine in remedy of varied illnesses, use of nanomedicines for diagnostic reasons, expertise of nanomedicines, and new traits in nanobiomedical research.

this can be the 1st particular guide in particular addressing quite a few elements of nanobiomedicine. Readers are handled to state-of-the-art examine and the most recent info from major researchers during this area.

Readership: lecturers, researchers, graduate scholars and execs drawn to modern nanomedicine.

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